In today's world, where the ageing population is growing, the desire for solutions that promise a longer and healthier life is increasing. One such solution that has captured both public and scientific attention is Nicotinamide Mononucleotide (NMN). NMN is believed to have the potential to slow down the ageing process and address age-related health issues. In this blog post, we'll delve into the current understanding of NMN, its potential benefits, and its role in combating the effects of ageing.
Understanding NMN: Nicotinamide Mononucleotide (NMN) is a naturally occurring compound present in various plant and animal sources of food. It plays a crucial role in the synthesis of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for numerous biochemical reactions in the body. NAD+ levels tend to decrease with age, contributing to mitochondrial dysfunction, oxidative stress, DNA damage, cognitive decline, and inflammation. NMN, by serving as an NAD+ precursor, shows to increase NAD+ levels, which may slow down these age-related processes.
In vitro and animal studies have reported positive outcomes from NMN supplementation.
Promising Benefits of NMN: Several studies conducted on cells, animal models, and a limited number of human trials have revealed encouraging results regarding the potential benefits of NMN:
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Enhanced Metabolic Health: NMN has shown potential in improving insulin sensitivity, lipid profiles, and glucose metabolism, which are particularly relevant in age-induced type 2 diabetes.
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Cardiovascular Well-Being: NMN has demonstrated promise in enhancing vascular function, reducing oxidative stress, and elevating NAD+ levels, thereby potentially benefiting heart health.
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Cognitive Function: NMN supplementation has exhibited the potential to mitigate age-related cognitive decline and enhance memory.
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Fertility Support: NMN has been found to rejuvenate oocyte quality, potentially aiding fertility in ageing females.
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Neurodegenerative Disease: NMN shows promise in reducing the risk of neurodegenerative conditions such as Alzheimer's and Parkinson's by improving mitochondrial function and reducing inflammation.
In conclusion Nicotinamide Mononucleotide (NMN) holds significant promise as a potential anti-aging solution. While existing research is promising, to fully understand its potential and its place in anti-aging strategies, further in-depth research and extensive clinical trials are necessary. In a market inundated with NMN-based products, consumers should exercise caution and seek products backed by credible scientific research that demonstrates their efficacy. The quest for a longer, healthier life continues, and NMN may play a pivotal role in that journey.
This blog post draws from the knowledge and research from 'The Journal of Advanced Research', 37 (2022), pg. 267-278, which was funded from Education New Zealand, New Zealand China Tripartite Research Collaboration Fund – AUT 13772 to Professors Jun Lu, Jinyao Li, Tianlei Ying and Baohong Zhang; Professor Jun Lu also has received funding support from EZZ Life Science Holdings Pty Ltd.
Link to the Journal article below:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039735/pdf/main.pdf